Kumar, Jogendra published the artcileEnhancing the Extent of Enolization for α-C-H Bonds of Aliphatic Carboxylic Acid Equivalents via Ion Pair Catalysis: Application toward α-Chalcogenation, Related Products of isoquinoline, the main research area is thioether selenoether preparation regioselective; aliphatic carboxamide thiol thiolation potassium phosphate catalyst; diselenide aliphatic carboxamide selenylation potassium phosphate catalyst.
In general, the α-functionalization of carboxylic acid derivatives RCH2C(O)NHR1 [R = Me, n-Bu, Ph, 3-thienyl, etc.; R1 = pyridin-2-yl, 4-Methylpyridin-2-yl, pyrimidin-2-yl, etc.] requires either a transition metal catalyst or a stoichiometric activating agent/strong base/external additive. A transition metal free α-chalcogenation of aliphatic carboxylic acid equivalent was reported via ion pair formation using K3PO4 as a catalyst. Mild conditions, broad scope, scalability of the process, attaining bioactive glucokinase activators, and some synthetic intermediates establish merits of the strategy.
Journal of Organic Chemistry published new progress about C-H bond activation. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem