Min, Xiao-Long published the artcileAxial-to-Central Chirality Transfer for Construction of Quaternary Stereocenters via Dearomatization of BINOLs, Related Products of isoquinoline, the main research area is spiro benzochromene naphthalenone asym synthesis; binaphthol dearomatization axial chirality transfer propargyl carbonate enantioselective spirocyclization.
Herein, an axial-to-central chirality transfer strategy for the synthesis of chiral quaternary stereocenters via dearomatization of (S)-BINOLs is disclosed. The reaction of (S)-BINOL with a wide range of propargyl carbonates I (R = Me, cyclopropyl, Ph, 4-ClC6H4, 1-naphthyl, 2-benzothienyl, etc.) proceeded smoothly to afford chiral spiro compounds II in high yields with excellent enantioselectivities. In addition, the strategy was extended to kinetic resolution of rac-BINOLs albeit with moderate s value.
Organic Letters published new progress about Dearomatization. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Related Products of isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem