Ruyet, Louise published the artcileZ-Selective Pd-catalyzed 2,2,2-trifluoroethylation of acrylamides at room temperature, Synthetic Route of 104-01-8, the main research area is quinolinyl acrylamide trifluoroethyl mesityliodonium trifluoromethanesulfonate palladium catalyst diastereoselective trifluoroethylation; quinolyl trifluoropentenamide preparation.
A straightforward 2,2,2-trifluoroethylation of acrylamides by Pd-catalyzed C-H bond activation was reported by using a fluorinated hypervalent iodine reagent as a coupling partner. At room temperature, this additive-free approach allowed the synthesis of Z-2,2,2-trifluoroethylated acrylamides (19 examples, up to 73% yield) in a stereoselective manner. Under these mild reaction conditions, the methodol. turned out to be functional group tolerant and mechanistic studies gave us a better understanding of the transformation.
Chemical Communications (Cambridge, United Kingdom) published new progress about Diastereoselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem