Ran, Xiaoyun published the artcileA novel route to unsymmetrical disubstituted ureas and thioureas by HMPA catalyzed reductive alkylation with trichlorosilane, Product Details of C2H6N2O, the main research area is unsym disubstituted urea preparation chemoselective; aldehyde monosubstituted urea reductive alkylation HMPA catalyst; ketone monosubstituted urea reductive alkylation HMPA catalyst; disubstituted thiourea unsym preparation chemoselective; monosubstituted thiourea aldehyde reductive alkylation HMPA catalyst; thiourea monosubstituted ketone reductive alkylation HMPA catalyst.
An hexamethylphosphoramide (HMPA) catalyzed reductive alkylation of ureas and thioureas with trichlorosilane under mild reaction conditions was developed. Both aldehydes and ketones could be used as efficient alkylation reagents in this method to obtain unsym. disubstituted ureas R1NHC(O)NHR2 [R1 = n-Pr, cyclohexyl, Bn, etc.; R2 = Me, Ph, PhC(O), etc.] and thioureas R3NHC(S)NHR4 [R3 = n-Pr, Bn, CH2CH=CHPh, etc.; R4 = Me, Ph, 4-MeOC6H4, 4-FC6H4] in moderate to high yields. A variety of di- and trisubstituted ureas and thioureas were easily prepared by this new reductive alkylation method. This protocol exhibited excellent functional group tolerance, chemoselectivity and practicality.
Organic Chemistry Frontiers published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, Product Details of C2H6N2O.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem