Shaabani, Shabnam published the artcileAutomated and accelerated synthesis of indole derivatives on a nano-scale, Product Details of C9H10O3, the main research area is indoline diversity oriented nano scale synthesis; cyclic Schiff base in situ preparation Ugi type reaction; phenyl hydrazine aldehyde Fischer indolization.
For the first time use of acoustic droplet ejection technol. and fast quality control was described to screen the efficiency of synthetic reactions on a nanomole scale in an automated and miniaturized fashion. The interrupted Fischer indole combined with Ugi-type reactions yielded several attractive drug-like indole scaffolds such as I [R1 = H, 5-Me, 4,6-di-Me, 5-MeO, 7-Br; R2 = Me, Et, ; R3 = Me, Et; R2R3 = (CH2)5, (CH2)2O(CH2)2, (CH2)2NBoc(CH2)2; R4 = i-Pr, cyclohexyl, 4-MeOC6H4, etc.; R5 = t-Bu, 2-pyrrolyl, 2-indolyl, etc.], tetrazole II and imino hadantoin e.g., III. In 384-well plates, a diverse set of interrupted Fischer indole intermediates were produced and reacted with the tricyclic hydantoin backbone in a 2-step sequence. Similarly, preformed Fischer indole intermediates were used to produce diverse sets of Ugi products and the efficiency was compared with that of the in situ method. Multiple reactions were performed again on a preparative millimole scale, showing scalability from nano to mg and thus synthetic utility. An unprecedented large number of building blocks were used for fast scope and limitation studies (68 isocyanides, 72 carboxylic acids). Miniaturization and anal. of the generated big synthesis data enabled deeper exploration of the chem. space and permitted the gain of knowledge that was previously impractical or impossible, such as the rapid survey of reactions and building block and functional group compatibility.
Green Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem