Shi, Dunfa published the artcileSynthesis of Secondary and Tertiary Alkyl Boronic Esters by gem-Carboborylation: Carbonyl Compounds as Bis(electrophile) Equivalents, Quality Control of 1205-17-0, the main research area is secondary tertiary alkyl boronic ester preparation; carboborylation carbonyl compound aldehyde ketone stereoselective; alkyl boronic esters; asymmetric catalysis; boron; carboborylation; copper catalysis.
An unprecedent gem-carboborylation of aldehydes and ketones provides access to various secondary and tertiary alkyl boronic esters. The addition of B2pin2 to a carbonyl compound generates α-oxyl-substituted alkyl boron species. Organolithium and Grignard reagents are then applied as C nucleophiles for the 1,2-metalate rearrangement process. The organolithium reagents can also be generated by C-H lithiation or halogen/lithium exchange. The use of chiral ligands led to the generation of chiral alkyl boronic esters in enantioenriched form, demonstrating that the enantioselectivity of this transformation is catalyst-controlled.
Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Quality Control of 1205-17-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem