Trost, Barry M. published the artcileBranched aldehydes as linchpins for the enantioselective and stereodivergent synthesis of 1,3-aminoalcohols featuring a quaternary stereocenter, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is aminoalc preparation enantioselective diastereoselective; aldehyde Mannich aldol Henry alkyne addition zinc prophenol catalyst.
The use of branched aldehydes e.g., benzyl (S)-(1-(4-fluorophenyl)-2,2-dimethyl-3-oxopropyl)carbamate as versatile linchpins for various Zn-prophenol-catalyzed C-C bond-forming reactions to efficiently construct enantioenriched 1,3-aminoalcs. e.g., I bearing an acyclic quaternary stereogenic center was reported. The ability of the Zn-ProPhenol catalyst to selectively activate ambiphilic aldehydes first as nucleophiles for Mannich reactions and then as electrophiles for aldol, Henry and alkyne addition reactions allows for the one-pot synthesis of complex stereotriads from common building blocks. Moreover, this approach can be diastereodivergent by simply selecting the proper catalyst combination. Overall, this catalytic method directly transforms simple and readily available aldehydes into highly functionalized compounds and provides streamlined access to valuable 1,3-aminoalcs. relevant to the synthesis of biol. important mols.
Nature Catalysis published new progress about Addition reaction catalysts, stereoselective. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem