Ye, Chen-Xi published the artcileStereocontrolled 1,3-nitrogen migration to access chiral α-amino acids, Application In Synthesis of 104-01-8, the main research area is chiral amino acid preparation regioselective enantioselective; azanyl ester preparation amination ruthenium iron catalyst; carboxylic acid hydroxylamine coupling reaction.
Here a protocol for the economical and practical synthesis of optically active α-amino acids RNHC(R1)(R2)C(O)OH (R = Ts, Ms, C(O)OMe, (2,2,2-trichloroethoxy)carbonyl; R1 = H, Me; R2 = pent-2-yn-1-yl, 4-methylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) based on an unprecedented stereocontrolled 1,3-nitrogen shift was reported. The method employs abundant and easily accessible carboxylic acids R1CH(R2)C(O)OH as starting materials, which are first connected to a nitrogenation reagent, followed by a highly regio- and enantioselective ruthenium- or iron-catalyzed C(sp3)-H amination. This straightforward method displays a very broad scope, providing rapid access to optically active α-amino acids with aryl, allyl, propargyl and alkyl side chains, and also permits stereocontrolled late-stage amination of carboxylic-acid-containing drugs and natural products.
Nature Chemistry published new progress about Amination catalysts (regio-, stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem