Arokianathar, Jude N. published the artcileIsothiourea-Catalyzed Enantioselective α-Alkylation of Esters via 1,6-Conjugate Addition to para-Quinone Methides, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is alkylated ester enantioselective diastereoselective preparation; nitrophenyl ester isothiourea catalyzed enantioselective alkylation para quinone methide; 1,6-conjugate addition; ammonium enolate; aryloxide; ester functionalization; isothiourea; quinone methide.
The isothiourea-catalyzed enantioselective 1,6-conjugate addition of para-nitrophenyl esters to 2,6-disubstituted para-quinone methides was reported. Para-nitrophenoxide, generated in situ from initial N-acylation of the isothiourea by the para-nitrophenyl ester, was proposed to facilitate catalyst turnover in this transformation. A range of para-nitrophenyl ester products could be isolated, or derivatized in situ by addition of benzylamine to give amides at up to 99% yield. Although low diastereocontrol was observed, the diastereoisomeric ester products were separable and formed with high enantiocontrol (up to 94:6 er).
Molecules published new progress about Alkylation catalysts, stereoselective. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem