Jacquier, Valerie published the artcileCharacterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds, Product Details of C11H12O3, the main research area is olfactory receptor OR1740 transport membrane odorant structure olfaction; helional lilial foliaver cyclosal aldehyde methyltolylpropionaldehyde OR1740 receptor; methylhydrocinnamaldehyde methylphenylpentanal trifernal piperonal vanillin OR1740 receptor recognition; hydrocinnamaldehyde bourgeonal methylcinnamaldehyde aldehyde methyl group carbon chain OR1740.
Mol. properties of odorant compounds essential for activation of the human olfactory receptor hOR17-40 were investigated using a collection of 23 variants of its cognate ligand helional. Coupling receptor activation to an optically detectable intracellular Ca2+ ion flux allowed dose-dependent screening of different odorant mols. in human embryonic kidney (HEK)293 cells. We found an extended collection of activating ligands and provide first evidence for hOR17-40-specific antagonists. The C-terminal fusion of enhanced green fluorescent protein to the hOR17-40 retained full receptor function and permitted the selection of cells with defined receptor expression levels, which was an essential step for optimizing our screening protocol. Interestingly, cells with a low EGFP fluorescence intensity exhibited efficient hOR17-40 cell surface targeting and odorant-evoked signal transduction; in contrast, highly fluorescent cells displayed mainly incorrectly targeted, intracellular receptors. Fluorescence-activated cell sorting was used to sep. hOR17-40-expressing cells on the basis of their endogenous EGFP fluorescence intensity, thereby increasing the fraction of odorant-responsive cells to up to 80% of the total cell number
Journal of Neurochemistry published new progress about Cell membrane (OR17-40 translocation to). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem