Tan, Chen published the artcilePractical Synthesis of Phosphinic Amides/Phosphoramidates through Catalytic Oxidative Coupling of Amines and P(O)-H Compounds, Category: isoquinoline, the main research area is phosphinic amide phosphoramidate preparation; catalytic oxidative coupling amine organophosphorus compound green chem stereoselective; cross-coupling; late-stage functionalization; phosphinic amides; phosphoramidates; phosphorus.
Herein, we report a highly efficient ZnI2-triggered oxidative cross-coupling reaction of P(O)-H compounds and amines. This operationally simple protocol provides unprecedented generic access to phosphinic amides/phosphoramidate derivatives in good yields and short reaction time. Besides, the reaction proceeds under mild conditions, which avoids the use of hazardous reagents, and is applicable to scale-up syntheses as well as late-stage functionalization of drug mols. The stereospecific coupling is also achieved from readily available optically enriched P(O)-H compounds
Chemistry – A European Journal published new progress about Diastereoselective synthesis. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem