Young, Claire M. published the artcileEvaluating aryl esters as bench-stable C(1)-ammonium enolate precursors in catalytic, enantioselective Michael addition-lactonizations, Product Details of C9H10O3, the main research area is keto ester preparation enantioselective diastereoselective; trifluoromethyl enone trichlorophenyl ester Michael lactonization methanolysis isothiourea catalyst; dihydropyranone preparation enantioselective diastereoselective; trichlorophenyl ester trifluoromethyl enone Michael addition lactonization isothiourea catalyst.
An evaluation of a range of aryl, alkyl and vinyl esters as prospective C(1)-ammonium enolate precursors in enantioselective Michael addition-lactonization processes with (E)-trifluoromethylenones using isothiourea catalysis was reported. Electron deficient aryl esters were required for reactivity, with 2,4,6-trichlorophenyl esters providing optimal product yields. Catalyst screening showed that tetramisole was the most effective isothiourea catalyst, giving the desired dihydropyranone products I [Ar = Ph, 4-MeC6H4, 4-F3CC6H4; Ar1 = Ph] in excellent yield and stereoselectivity (up to 90 : 10 dr and 98 : 2 er). The scope and limitations of this process were evaluated, with a range of keto ester products II [Ar1 = Ph, 2-furyl, 4-MeC6H4, 3-MeOC6H4, 4-BrC6H4] being generated after ring-opening with MeOH to give stereodefined dihydropyranones with excellent stereocontrol (10 examples, typically ∼90 : 10 dr and >95 : 5 er).
Organic & Biomolecular Chemistry published new progress about Diastereoselective synthesis. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Product Details of C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem