Uemura, Takahito published the artcileEasy access to both enantiomers of 5-hydroxyequol and 3-(4-hydroxyphenyl)chroman-8-ol, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is hydroxyequol hydroxyphenyl chromanol preparation enantioselective; trimethoxyphenyl dimethoxyphenyl propanal diaryliodonium salt arylation MacMillan catalyst cyclization.
5-Hydroxyequol, a biol. active isoflavone metabolite from genistein, has been synthesized enantioselectively from 3-(2,4,6-trimethoxyphenyl)propanal by using MacMillans’ asym. α-arylation protocol of carbonyl compound (S)- and (R)-5-hydroxyequols have been obtained in 90% and 88% ee, resp., by employing enantiomeric imidazolidinone catalysts derived from D- and L-phenylglycines. The absolute configuration of natural 5-hydroxyequol has been definitely assigned to (S)-stereochem. (S)- And (R)-3-(4-hydroxyphenyl)chroman-8-ol, an unnatural equol isomer, have also been synthesized for the first time in 76% and 84% ee, resp.
Results in Chemistry published new progress about Arylation catalysts, stereoselective. 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem