Wang, Jian published the artcileMonodentate transient directing group promoted Pd-catalyzed direct ortho-C-H arylation and chlorination of α-ketoesters for three-step synthesis of Clopidogrel racemate, Computed Properties of 151-10-0, the main research area is iodobenzene ketoester palladium catalyst regioselective arylation; biaryl ketoester preparation; keto ester chlorosuccinimde palladium catalyst regioselective chlorinaton; chlorophenyl ketoester preparation.
An unprecedented direct ortho C-H arylation and chlorination of α-ketoesters were successfully accomplished by using a combination of monodentate transient directing group strategy and palladium catalysis. The in situ formed imine changed the bidentate coordination model of α-ketoesters to monodentate, so as to fulfill the ortho C-H activation. Importantly, the key binuclear cyclopalladium intermediate bridged by acetate anion was unambiguously characterized by X-ray diffraction, which solidly supports the proposed mechanism. The practical utility was further depicted as facile access to oral antiplatelet agent Clopidogrel racemate via subsequent two-step derivatization.
Tetrahedron published new progress about Arylation catalysts (regioselective). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem