Formation of ethoxyhydroquinazolinone by attack of an ester carbonyl oxygen at a cyano group of an enamine was written by Bischoff, Christian;Schroeder, Edith. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1985.Synthetic Route of C10H10N2O2 The following contents are mentioned in the article:
Et 2-oxocyclohexanecarboxylate was treated with H2NCN to give 4-ethoxy-2,3,5,6,7,8-hexahydroquinazolin-2-one. Bu 2-oxocyclopentanecarboxylate and H2NCN gave Bu 3-cyanaminocyclopent-1-enecarboxylate. 2-Oxocyclohexanecarboxamide reacted with EtO2CCH2CN and NaOH to give 4-cyanooctahydroisoquinoline-1,3-dione and with NH4OAc to give the Et cyclohexylidenecyanoacetate I. I was treated with NH3, H2NNH2, or cyclohexylamine to give the cyanohydroquinazolinedione salts II (R = H, NH2, cyclohexyl). This study involved multiple reactions and reactants, such as 1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6Synthetic Route of C10H10N2O2).
1-Hydroxy-3-oxo-2,3,5,6,7,8-hexahydroisoquinoline-4-carbonitrile (cas: 52903-71-6) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Synthetic Route of C10H10N2O2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem