Improved synthesis of 1-chloro-6-methoxy-isoquinolin-3-ol and its derivatives was written by Zheng, Zhizhen Barbara;Wang, Alan Xiangdong;Scola, Paul;D’Andrea, Stanley. And the article was included in Synthetic Communications in 2009.COA of Formula: C10H8ClNO2 The following contents are mentioned in the article:
A convenient and efficient synthetic route to 1-chloro-6-methoxy-isoquinolin-3-ol and its derivatives was reported. This new method involved carboxylation of 4-methoxy-2-methylbenzonitrile, subsequent conversion of the resulting 2-cyano-5-methoxy-phenylacetic acid to its acid chloride, and acid-promoted cyclization of the 2-cyano-5-methoxy-phenyl-acetyl chloride. This procedure offers a better overall yield than the previously reported route and is also less hazardous and more reproducible. This study involved multiple reactions and reactants, such as 1-Chloro-6-methoxyisoquinolin-3(2H)-one (cas: 55086-31-2COA of Formula: C10H8ClNO2).
1-Chloro-6-methoxyisoquinolin-3(2H)-one (cas: 55086-31-2) belongs to isoquinoline derivatives. Quinoline is a catabolite of tryptophan, the basic structure of some antihypertensive drugs, such as the peripheral vasodilators prazosin and doxazosin. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.COA of Formula: C10H8ClNO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem