Nakamura, Kenji published the artcileA 90-day subchronic toxicity study of 5-methyl-2-phenyl-2-hexenal in F344 rats, Formula: C13H16O, the main research area is subchronic toxicity MPH adverse effects; 5-Methyl-2-phenyl-2-hexenal; F344 rats; Flavoring agent; Subchronic toxicity.
5-Methyl-2-phenyl-2-hexenal (MPH) has been used as a flavoring agent. In the present study, we performed a subchronic toxicity study in male and female F344 rats with oral administration of MPH by gavage at 0, 8, 24 and 70 mg/kg body weight (BW)/day for 90 days. No mortality or clin. signs were observed during the exptl. period. Body weight and food consumption for all treated groups of both sexes were essentially the same as for the resp. control groups. Hematol. examination demonstrated significant decreases in monocyte counts for females given 24 and 70 mg/kg BW/day. However, these changes were not substantial and no related histopathol. changes were observed, suggesting that these changes were not toxicol. significant. Among organ weights, the absolute and/or relative weights of testes and liver were significantly increased in the 70 mg/kg BW/day groups of males and females, resp., but no related histopathol. changes were observed, suggesting that these changes did not reflect adverse effects. In addition, no treatment-related histopathol. changes were observed for any of the tissues examined Based on the overall data, the no-observed-adverse-effect level (NOAEL) for MPH was determined to be 70 mg/kg BW/day, the highest dose tested, in both male and female rats.
Food and Chemical Toxicology published new progress about Adrenal gland. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Formula: C13H16O.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem