La Manna, Pellegrino published the artcileGreen, Mild, and Efficient Friedel-Crafts Benzylation of Scarcely Reactive Arenes and Heteroarenes under On-Water Conditions, Category: isoquinoline, the main research area is arene benzyl chloride resorcinarene macrocycle catalyst Friedel Craft benzylation; benzylarene regioselective preparation green chem; alkylation; catalysis; hydrogen bonds; resorcinarenes; supramolecular chemistry.
Metal-free Friedel-Crafts benzylation (FCB) of scarcely reactive arenes and heteroarenes was performed under on-water conditions by an environmentally sustainable procedure. The catalytic strategy exploited the hydrophobicity of the resorcinarene macrocycle e.g., I. The proposed mechanism was based on the activation of benzyl chloride by H-bonding interactions with catalyst e.g., I. In fact, under on-water conditions the hydrophobic amplification of the strength of the H-bonding interactions between the OH groups of the resorcinarene catalyst and the chlorine atom of benzyl chloride led to polarization of the C-Cl bond, which consequently promoted electrophilic attack of the π nucleophile. Thus, many arenes and heteroarenes were efficiently benzylated under mild on-water conditions by using resorcinarene I as catalyst. The FCB of benzene was industrially relevant for the synthesis of diphenylmethane and hence the on-water procedure was extended to the gram-scale synthesis of diphenylmethane, starting from benzene and benzyl chloride in the presence of resorcinarene catalyst I.
ChemSusChem published new progress about Benzylation catalysts (regioselective). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem