Demidov, Maxim R. published the artcileThree-component synthesis of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones and their reductive rearrangement into 4H,5H-thiochromeno[4,3-b]pyran-5-ones, Synthetic Route of 86-51-1, the main research area is thiochromenopyranone preparation; acyl thiochromenofuranone preparation reductive rearrangement; pyridinium acyl methylide aldehyde hydroxythiocoumarin multicomponent.
Three-component condensation of in situ generated pyridinium acyl methylides with aromatic aldehydes and 4-hydroxythiocoumarin led to a series of 2-acyl-dihydro-thiochromenofuranones I [R1 = Ph, 3-O2NC6H4, 2-naphthyl, etc.; R2 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.]. The reaction proceeded diastereoselectively with the formation of trans-isomers and represented a cascade process involving the Knoevenagel condensation, carbo-Michael reaction and intramol. nucleophilic substitution. The subsequent redox rearrangement of 2-acyl-2,3-dihydro-4H-thiochromeno[4,3-b]furan-4-ones by the action of Zn and ZrCl4 granted access to 4H,5H-thiochromeno[4,3-b]pyran-5-ones II.
Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem