Cheng, Wei-Chieh published the artcileFurther insights on structural modifications of muramyl dipeptides to study the human NOPD2 stimulating activity, Category: isoquinoline, the main research area is muramyl dipeptide structural modification human NOPD2 stimulating activity; dipeptide muramyl synthesis Staudinger reaction Click chem; Click chem azide alkyne cycloaddition copper catalyst; Biological activity; Innate immunity; Muramyl dipeptide (MDP); NOD2; Peptidoglycan; Structure activity relationship.
A series of muramyl dipeptide (MDP) analogs with structural modifications at the C4 position of MurNAc and on the D-iso-glutamine (isoGln) residue of the peptide part were synthesized. The C4-diversification of MurNAc was conveniently achieved by using CuAAC click strategy to conjugate an azido muramyl dipeptide precursor with structurally diverse alkynes. D-Glutamic acid (Glu), replaced with isoGln, was applied for the structural diversity through esterification or amidation of the carboxylic acid. In total, 26 MDP analogs were synthesized and bio-evaluated for the study of human NOD2 stimulation activity in the innate immune response. Interestingly, MDP derivatives with an ester moiety are found to be more potent than reference compound MDP itself or MDP analogs containing an amide moiety. Among the varied lengths of the alkyl chain in ester derivatives, the MDP analog bearing the D-glutamate dodecyl (C12) ester moiety showed the best NOD2 stimulation potency.
Chemistry – An Asian Journal published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem