Bi, Tongyu published the artcileNatural scaffolds-inspired synthesis of CF3-substituted macrolides enabled by Rh-catalyzed C-H alkylation macrocyclization, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is trifluoromethyl macrolide preparation diastereoselective chemoselective antiinflammatory.
Inspired by the key scaffolds of rapamycin and FR252921, a Rh(III)-catalyzed C-H alkylation macrocyclization, which enables access to CF3-substituted macrolides, is reported. DFT calculations revealed that the chemoselectivity between C-H alkylation and olefination macrocyclization is highly controllable. Moreover, the unique CF3-substituted macrolides showed potent anti-inflammation activities against TNF-α, IL-6 and CCL2 mRNA expression.
Chinese Chemical Letters published new progress about Alkylation catalysts (chemoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem