Yamashita, Shuji et al. published their research in Tetrahedron Letters in 2009 | CAS: 75476-83-4

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Synthetic Route of C9H6IN

Efficient and stereoselective installation of isoquinoline: formal total synthesis of cortistatin A was written by Yamashita, Shuji;Kitajima, Kazuki;Iso, Kentaro;Hirama, Masahiro. And the article was included in Tetrahedron Letters in 2009.Synthetic Route of C9H6IN The following contents are mentioned in the article:

The highly stereoselective attachment of isoquinoline onto the steroidal framework of cortistatin A (I) was achieved. The synthetic strategy featured a Ce-mediated nucleophilic addition of an isoquinoline unit to the sterically congested ketone followed by formation of the Ph thiocarbamate, and subsequent stereoselective radical reduction The new method resulted in a formal total synthesis of cortistatin A. This study involved multiple reactions and reactants, such as 7-Iodoisoquinoline (cas: 75476-83-4Synthetic Route of C9H6IN).

7-Iodoisoquinoline (cas: 75476-83-4) belongs to isoquinoline derivatives. Quinoline and isoquinoline skeletons are among the most attractive frameworks with a wide range of biological and pharmacological activities. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Synthetic Route of C9H6IN

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem